|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These findings will assist in the evaluation of roles of HSP47 in collagen misfolding and human diseases such as cancer and bone disorders.
|
30986427 |
2020 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
These findings will assist in the evaluation of roles of HSP47 in collagen misfolding and human diseases such as cancer and bone disorders.
|
30986427 |
2020 |
|
Bone Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings will assist in the evaluation of roles of HSP47 in collagen misfolding and human diseases such as cancer and bone disorders.
|
30986427 |
2020 |
|
Fibrosis, Liver
|
0.360 |
Biomarker
|
disease |
BEFREE |
Thereafter, according to the co-expression network analysis, the regulations of three core genes (Cenpp, Cyp2c55, Serpinh1) were verified that might be targets for treating liver fibrosis.
|
31047894 |
2019 |
|
Osteogenesis Imperfecta
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
SERPINH1 mutations have been associated with one of the rarest forms of recessively inherited osteogenesis imperfecta (OI) with a moderate to severe phenotype.
|
31179625 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These results suggest that binding of HSP47 to DDR2 increases DDR2 stability and regulates its membrane dynamics and thereby enhances cancer cell migration and invasion.
|
31570520 |
2019 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
HSP47 silencing reduced DDR2 protein stability, accompanied by suppressed cell migration and invasion.
|
31570520 |
2019 |
|
Tumor Progression
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Given that DDR2 has a crucial role in the epithelial-to-mesenchymal transition and cancer progression, targeting the HSP47-DDR2 interaction might be a potential strategy for inhibiting DDR2-dependent cancer progression.
|
31570520 |
2019 |
|
Chorioamnionitis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The rates of chorioamnionitis and PPROM were significantly higher in the amniocentesis group (17 versus 2%, <i>p</i> = .0008 and 26 versus 13%, <i>p</i> = .03 respectively).
|
31177883 |
2019 |
|
Chorioamnionitis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our findings demonstrate that commonly used US markers were similar in pregnancies complicated by PPROM between women delivered for suspected chorioamnionitis and those delivered for other indications, and performed poorly in predicting adverse neonatal outcomes.This article is protected by copyright.All rights reserved.
|
31332850 |
2019 |
|
Chronic graft-versus-host disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
VA-lip HSP47 eye drops are a promising prophylactic and therapeutic option against dry eye syndrome in chronic GVHD.
|
30940635 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
These results suggest that binding of HSP47 to DDR2 increases DDR2 stability and regulates its membrane dynamics and thereby enhances cancer cell migration and invasion.
|
31570520 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
ND-L02-s0201/BMS-986263 is a lipid nanoparticle (LNP) drug product containing a heat shock protein 47 (HSP47)-specific small interfering ribonucleic acid (siRNA) and being developed for the treatment of liver and idiopathic pulmonary fibrosis.
|
31332587 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
<i>SNHG6</i>, serpin family H member 1 (<i>SERPINH1</i>) and miR-139-5p expression levels in HCC tissues and cells were determined by quantitative real-time PCR (qRT-PCR).
|
31258024 |
2019 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using the combined Sanger sequencing and TaqMan junction assays, unique and common expressions of spliced variants including enzyme regulators (ARHGEF2, SERPINH1), chromatin modifiers (DEK, CDK9, RBBP7), RNA-binding proteins (SRSF3, RBM27, MATR3, YBX1), and receptors (ADRM1, CD44v8-10, vitamin D receptor, ROR1) were determined in HCC tumors.
|
30637779 |
2019 |
|
Connective Tissue Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In this Review, we discuss the role and function of Hsp47 in vertebrate cells and its role in connective tissue disorders.
|
30541925 |
2019 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSP47 is increased in patients with CRS without nasal polyps.
|
31664133 |
2019 |
|
Dry Eye Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
VA-lip HSP47 eye drops are a promising prophylactic and therapeutic option against dry eye syndrome in chronic GVHD.
|
30940635 |
2019 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We explored the role of heat shock protein 47 (HSP47) in ocular GVHD and developed a novel antifibrotic topical therapy using vitamin A-coupled liposomes containing HSP47 small interfering RNA (siRNA) against HSP47 (VA-lip HSP47).
|
30940635 |
2019 |
|
Nasal Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSP47 is increased in patients with CRS without nasal polyps.
|
31664133 |
2019 |
|
Chronic sinusitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSP47 is required for the production of collagen and serves an important role in tissue remodeling, a pathophysiologic mechanism of chronic rhinosinusitis (CRS).
|
31664133 |
2019 |
|
OSTEOGENESIS IMPERFECTA, TYPE X
|
0.910 |
GeneticVariation
|
disease |
BEFREE |
Mutation in serpin peptidase inhibitor clade H, member 1 (SERPINH1), which encodes heat shock protein 47 (HSP47), leads to rare autosomal recessive OI type X.
|
29520608 |
2018 |